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Gillan-the Barre Syndrome Clinical Characteristics and Immunoglobulin Gillan-the Barre Syndrome Caus

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Tutor: GuoShuYing
School: Hebei Medical University
Course: Neurology
Keywords: gillan-the barre syndrome,Clinical characteristics,Thetriggers ivig treatment
CLC: R745.43
Type: Master's thesis
Year:  2014
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Abstract:
Objective: Through to the clinical data of75cases of GBS systemevaluation, discuss the disease characteristics and GBS intravenous drip intothe large dose of gamma globulin gillan-the barre syndrome caused bydifferent causes of treatment effect, to gillan-provides the reference for thediagnosis, treatment of the barre syndrome, to alleviate the burden of patientsand improve the patient’s quality of life.Methods: a systematic review and analysis in January2012-December2013, hebei medical university second affiliated hospital neurology patientsdiagnosed with gillan-the barre syndrome patients in hospital medical records,patients with the clinical observation and analysis of the onset of patients withgender, age, season, inducing factors of the disease, patients with GBSpatients with first onset of symptoms, the patient illness development to peaktime, patients with paralysis of development mode, the tendon reflex, wellinvolvement and situation, the sensory disturbance of clinical symptoms,cranial nerve injury, autonomic nerve dysfunction, complications. Laboratoryand auxiliary examination including lumbar puncture time, determination ofcerebrospinal fluid pressure and biochemical examination and emgexamination of cerebrospinal fluid. Immunoglobulin therapy on analysis to thedifferent causes diarrhea, respiratory infections and disease before the event,no obvious incentive group compare the treatment effect.Results: In75patients with GBS,33.3%female,66.7%male, and theratio of2:1. The average patient age was36years old. The season of patientsin summer and autumn, the onset of summer in37.3%of the patients, theonset of autumn26.7%.1to3weeks before the onset of infection, accountingfor65.3%of all patients, and no obvious incentive events before onset patients accounted for34.7%, in the respiratory tract and digestive tract infection,accounted for38.7%and22.7%of patients, and virus infection, fatigue,operation, but also induced factors of vaccination. GBS patients with clinicalsymptoms with limb weakness, accounted for the study of patients with45.3%,followed by sensory disturbance, the study of21.3%patients. GBS patients inthe incidence of eighth±5.6days average reached the peak. The occurrenceand development of96%in patients with GBS disease in patients with limbweakness, in order for the development of lower limb weakness developedupper extremity weakness was the most common, accounting for30%. Thetendon reflex of patients:74.7%patients with tendon hyporeflexia, reflex inpatients with tendon25.3%disappear. Sensory disorder accounted for56%,the inhibitory nervous symptoms, accounted for33.3%, some patients willappear nervous irritation symptoms, accounted for17.3%, there are somepatients will appear at the same time inhibitory nervous symptoms and nervestimulation symptoms, accounted for5.3%of patients.52%of GBS patientsin the disease development in the injury of cranial nerve damage, mainly inthe facial nerve, accounted for the study of patients with21.3%, followed bythe glossopharyngeal and vagal nerve damage, the study of18.7%patients.Clinical manifestation of GBS color autonomic dysfunction to a bladderdysfunction and arrhythmia, accounted for22.7%and16%, the rest are nauseaand vomiting, skin flushing performance. Clinical study of intravenousimmunoglobulin on digestive tract infection, GBS therapy for patients withrespiratory tract infection, disease event or no obvious style of no statisticalsignificance, P was greater than0.05.Conclusion: Men more than women, patients with GBS incidence age isgiven priority to with young and middle-aged, the winter to summer fall most,most patients with GBS disease1to3weeks ago had obvious disease historyof infection and disease before the event, most of the patients with diseaseprogression rapidly,1to2weeks of illness development peak, patients withtypical performance for infection after said sexual slow paralysis of limbs,most of the patients from the distal limb to the body the proximal development, part of the patients can be developed from limb proximal to distal limb, withor without feeling disorder, including sensory disturbance is given priority towith hypoesthesia, also can appear myalgia, subjective feeling obstacle. Ranksfirst when lesions involving the cranial nerve damage is damage to the facialnerve, glossopharyngeal nerve and vagus nerve was second. Transient urinarydysfunction, arrhythmia was GBS patients with autonomic nerve dysfunction.Intravenous gamma globulin in the digestive tract infections, respiratoryinfections, disease type to type before the event or have no obvious effect ofthe treatment of patients with GBS were no significant statistical difference.
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