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Iron Deposition in Deep Grey Nuclei in Episodic and Chronic Migraine

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Tutor: ZhouJiYing
School: Chongqing Medical University
Course: Neurology
Keywords: episodic migraine,chronic migraine,iron deposition,3D-enhanced T2star weighted a
CLC: R747.2
Type: Master's thesis
Year:  2013
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Abstract:
Objective:By evaluate iron deposition of deep brain gray nucleus betweenepisodic migraine (EM) and chronic migraine (CM) by magnetic resonanceimaging (MRI), and evaluate the correlation of their values with headachehistory, headache frequency and intensity. We aided to provide a method todistinguish EM and CM, and discuss the physiopathologic changes andpathogenesis of migraine.Methods:Conventional MRI and3D-enhanced T2star weighted angiography(ESWAN) were performed in19EM patients,18CM (including9CMwithout medication overuse patients and9CM with medication overusepatients) and18cases of sex and age matched normal controls. Theregions of interests (ROIs), including substantia nigra (SN), red nucleus(RN), globus pallidus (GP), putamen (PUT), head of caudate nucleus (HCN)and thalamus (THA) were manually drown on the post-processed phaseimages. Mean phase values of each ROIs were obtained by signal process in neuroradiology (SPIN) software automatically. The mean phase values ofeach ROIs were taken the average of the values obtained from three adjacentsections, including the largest area of the ROIs and the superior and inferiorareas.Results:1)The mean phase values of all brain grey nuclei in migraine patientswere lower than those in the control group, including SN(p=0.01)andGP(p=0.003)2)The ages of the episodic migraine group, the chronic migrainegroup and the control group did not show significant difference (p=0.238).There were significant differences of the mean phase values of RN(p=0.020),SN (p=0.035)andGP (p=0.004)among the three groupsusing the one-way analysis of variance. The phase values of RN in episodicmigraine patients were significantly lower than that of chronic migrainepatients by further applying intergroup analysis(p=0.017). While the phasevalues of GP(p=0.003)in episodic migraine group were significantly lowerthan those of the control group.3)The age of the CM without medication overuse group and the CMwith medication overuse group did not show significant difference (p=0.697). And there were no significant differences of the mean phase values innuclei in these two groups.4)The mean phase values of each brain nuclei in migraine patients were not correlated with disease duration, headache frequency andheadache intensity. The mean phase values of each brain nuclei in episodicand chronic migraine patients were also not correlated with disease duration,headache frequency and headache intensity.Conclusions:We found the mean phase values of all brain grey nuclei in migrainepatients were lower than those in the control group, prompting there wereiron deposition in migraine patients. And we also found that there was moreiron deposition of RN in episodic migraine than that of chronic migraine.ESWAN can be helpful to distinguish between EM and CM bymeasuring iron deposition of the RN nuclei. But this was not applicablewhen distinguishing between CM without medication overuse group andCM with medication overuse group.
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