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Study of Antiosteoporotic Constituents of Erythrina Variegata L.

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Tutor: WangNaiLi HuangWenXiu ChenXinZi YaoXinSheng
School: Shenyang Pharmaceutical University
Course: Medicinal Chemistry
Keywords: Erythrina variegata L.,osteoporosis,UMR106 cell line,MTT method,ALP
CLC: R284
Type: Master's thesis
Year:  2004
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In the present dissertation, 130 species of Chinese medicinal herbs, collected at Guang xi region, were tested for their antiosteoporosis activities by bioassay using MTT method and osteoblast-like (OB-like) cells UMR106. Also the method and the cell model were used to guide and isolate antiosteoporotic constituents from those which caused proliferation of UMR106 cell line. With the results of above bioassay, phytochemical analysis of the bark of Erythrina variegata L. has now led to the isolation of twenty pure compounds. All of them structures were elucidated on the basis of physicochemical properties and spectra methods. Among them, compounds 8,15,18 and 20 are new isoflavones.The four new compounds were established as: 5, 4’-dihydroxy-2’-methoxy-8-(3, 3-dimethylally)-2", 2"-dimethylpyrano[5, 6: 6, 7] isoflavanone (8); 5,4’-dihydr-oxy-8-(3, 3-dimethylally)-2"-methoxyisopropyl-furano [4, 5: 6, 7]isoflavone (15); 5, 7,4’-trihydroxy-6-(3, 3-dimethyl-oxiranylmethyl)isoflavone (18); 5,4’-dihydr-oxy-8-(3, 3-dimethylally)-2"-hydroxymethyl-2"-methylpyrano[5, 6: 6, 7] isoflavone (20), and named as Eryvarins H, I, J, K.The known compounds were determined to be: 5, 4’-dihydroxy-8-(3, 3-dime-thylally)-2", 2"-dimethylpyrano[5, 6: 6, 7] isoflavone (1); stigmasterol (2); eryth-rinassinate B (3); 3-hydroxy-2’, 2’-dimethylpyrano[5, 6: 9, 10] pterocarpan (4); 5, 7- dihydroxy-8-(3, 3-dimethylally)-flavanone (5); 5, 4’-dihydroxy-2", 2"-dimethyl-
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